Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions

• Main Authors: René Miranda, Francisco J. Pérez, Gabriel A. Arroyo, Joel O. Martínez, Hortensia Rodríguez, M. Olivia Noguez, Osnieski Martín, Margarita Suárez, Vanessa Marcelino
• Format: Article
• Language: English
• Published: MDPI AG 2011-04-01
• Series: International Journal of Molecular Sciences
• Subjects: green approach; infrared irradiation; dihydropyridones; multicomponent reaction; Meldrum’s acid
• Online Access: http://www.mdpi.com/1422-0067/12/4/2641/

A green approach for the synthesis of a set of ten 4-aryl substituted-5-alcoxy carbonyl-6-methyl-3,4-dihydro-2(1H)-pyridones using Meldrum’s acid has been devised, the absence of solvent and the activation with infrared irradiation in addition to a multicomponent protocol are the main reaction conditions. The transformations proceeded with moderated yields (50–75%) with a reasonable reaction rate (3 h). It is worth noting that two novel molecules of the new class of the bis-3,4-dihydropyridones were also obtained. In addition, a comparison without the use of infrared irradiation was performed.