Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?

Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?

<p>Drug resistance of pathogens has necessitated the identification of novel targets for antibiotics. Thiamin (vitamin B1) is an essential cofactor for all organisms in its active form thiamin diphosphate (ThDP). Therefore, its metabolic pathways might be one largely untapped source of antibio...

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Main Author: Qinglin Du, Honghai Wang, Jianping Xie
Format: Article
Language:English
Published: Ivyspring International Publisher 2011-01-01
Series:International Journal of Biological Sciences
Online Access:http://www.biolsci.org/v07p0041.htm
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spelling doaj-0dabce018e6b4dd2b47f3f519c2318fe2020-11-24T22:06:50ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882011-01-01714152Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?Qinglin Du, Honghai Wang, Jianping Xie<p>Drug resistance of pathogens has necessitated the identification of novel targets for antibiotics. Thiamin (vitamin B1) is an essential cofactor for all organisms in its active form thiamin diphosphate (ThDP). Therefore, its metabolic pathways might be one largely untapped source of antibiotics targets. This review describes bacterial thiamin biosynthetic, salvage, and transport pathways. Essential thiamin synthetic enzymes such as Dxs and ThiE are proposed as promising drug targets. The regulation mechanism of thiamin biosynthesis by ThDP riboswitch is also discussed. As drug targets of existing antimicrobial compound pyrithiamin, the ThDP riboswitch might serves as alternative targets for more antibiotics.</p>http://www.biolsci.org/v07p0041.htm
collection DOAJ
language English
format Article
sources DOAJ
author Qinglin Du, Honghai Wang, Jianping Xie
spellingShingle Qinglin Du, Honghai Wang, Jianping Xie
Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?
International Journal of Biological Sciences
author_facet Qinglin Du, Honghai Wang, Jianping Xie
author_sort Qinglin Du, Honghai Wang, Jianping Xie
title Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?
title_short Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?
title_full Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?
title_fullStr Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?
title_full_unstemmed Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?
title_sort thiamin (vitamin b1) biosynthesis and regulation: a rich source of antimicrobial drug targets?
publisher Ivyspring International Publisher
series International Journal of Biological Sciences
issn 1449-2288
publishDate 2011-01-01
description <p>Drug resistance of pathogens has necessitated the identification of novel targets for antibiotics. Thiamin (vitamin B1) is an essential cofactor for all organisms in its active form thiamin diphosphate (ThDP). Therefore, its metabolic pathways might be one largely untapped source of antibiotics targets. This review describes bacterial thiamin biosynthetic, salvage, and transport pathways. Essential thiamin synthetic enzymes such as Dxs and ThiE are proposed as promising drug targets. The regulation mechanism of thiamin biosynthesis by ThDP riboswitch is also discussed. As drug targets of existing antimicrobial compound pyrithiamin, the ThDP riboswitch might serves as alternative targets for more antibiotics.</p>
url http://www.biolsci.org/v07p0041.htm
work_keys_str_mv AT qinglinduhonghaiwangjianpingxie thiaminvitaminb1biosynthesisandregulationarichsourceofantimicrobialdrugtargets
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