Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury

Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury

Ischemic brain injury triggers neuronal cell death by apoptosis via caspase activation and by necroptosis through activation of the receptor-interacting protein kinases (RIPK) associated with the tumor necrosis factor-alpha (TNF-α)/death receptor. Recent evidence shows RIPK inhibitors are neuroprote...

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Bibliographic Details
Main Authors: Shelly A Cruz, Zhaohong Qin, Alexandre F. R. Stewart, Hsiao-Huei Chen
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
ischemic brain injury; inflammation; macrophage; Dabrafenib; tumor necrosis factor-alpha; photothrombosis; receptor-interacting protein kinases; necroptosis; microglia; stroke; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=2;spage=252;epage=256;aulast=Cruz

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