A systems biology-based approach to deciphering the etiology of steatosis employing patient-derived dermal fibroblasts and iPS cells

A systems biology-based approach to deciphering the etiology of steatosis employing patient-derived dermal fibroblasts and iPS cells

Nonalcoholic fatty liver disease (NAFLD) comprises a broad spectrum of disease states ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). As a result of increases in the prevalences of obesity, insulin resistance, and hyperlipidemia, the number of people with hepatic steatosis cont...

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Bibliographic Details
Main Authors: Justyna eJozefczuk, Karl eKashofer, Ramesh eUmmanni, Frauke eHenjes, Samrina eRehman, Suzanne eGeenen, Wasco eWruck, Christian eRegenbrecht, Andriani eDaskalaki, Christoph eWierling, Paola eTurano, Ivano eBertini, Ulrike eKorf, Kurt eZatloukal, Hans eWesterhoff, Hans eLehrach, James eAdjaye
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-09-01
Series:Frontiers in Physiology
Subjects:
Induced Pluripotent Stem Cells
Lipid Metabolism
AKT/mTOR signaling
Glutathione metabolism
NAFLD
Sterol biosynthesis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00339/full

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