Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells

Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells

<p>Abstract</p> <p>Background</p> <p>Excessive secretion of IL-8 characterizes cystic fibrosis (CF). This has been attributed to excessive activation of epithelial cell I-κB Kinase and/or NFκB. Maximum IL-8 production requires 3 cooperative mechanisms: 1) release of the...

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Bibliographic Details
Main Authors: Saadane Aicha, Eastman Jean, Berger Melvin, Bonfield Tracey L
Format: Article
Language:English
Published: BMC 2011-10-01
Series:Journal of Inflammation
Online Access:http://www.journal-inflammation.com/content/8/1/26

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