Influence of Various Schemes of Pathogenetic Treatment on the State of Prooxidant-Antioxidant Homeostasis on Patients with Acute Hepatitis B and Concomitant Use of Alcohol in Hepatotoxic Doses

• Main Authors: O.V. Rуabokon, O.O. Furyk, N.S. Ushenina
• Format: Article
• Language: English
• Published: Publishing House Zaslavsky 2014-09-01
• Series: Aktualʹnaâ Infektologiâ
• Subjects: acute hepatitis B; prooxidant-antioxidant homeostasis; alcohol; L-arginine hydrochloride; thiotriazoline
• Online Access: http://ai.zaslavsky.com.ua/article/view/82425
• ISSN: 2312-413X; 2312-4148

The study involved 133 patients with acute hepatitis B aged from 18 to 60 years. The article shows that in patients with acute hepatitis B and concomitant chronic consumption of alcohol in hepatotoxic doses consumption, the height of disease is characterized by larger disturbances in prooxidant-antioxidant regulation due to the higher level of aldehyde phenylhydrazone of spontaneous oxidative modification of blood proteins and nitrites, which is combined with the low L-arginine content in blood serum. The period of convalescence in these patients is characterized by a higher level of aldehyde phenylhydrazones and ketone phenylhydrazones of spontaneous oxidative modification of blood proteins, a higher content of nitrites in combination with low L-arginine content in the blood serum, as compared with patients without concomitant liver disease. The use of L-arginine hydrochloride (Tivortin) and thiotriazoline in the treatment of patients with acute hepatitis B with chronic consumption of alcohol in hepatotoxic doses improves antioxidant-prooxidant processes by reducing the content of nitrites and ketone phenylhydrazones of spontaneous oxidative modification of blood proteins, increased content of L-arginine and catalase activity in blood serum, contributes to the normalization of alanine aminotransferase activity, and increased frequency of HBeAg — anti-HBe seroconversion compared with patients who are treated using only basic agents.