SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development

SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development

During embryonic development, it is vital to maintain rapid genome duplication. Here, the authors shed light on the mechanism by revealing that SSRP1 stimulates replication origin assembly on somatic nuclei in Xenopus laevis egg extract by promoting histone H1 eviction from somatic chromatin.

Bibliographic Details
Main Authors: Lucia Falbo, Erica Raspelli, Francesco Romeo, Simona Fiorani, Federica Pezzimenti, Francesca Casagrande, Ilaria Costa, Dario Parazzoli, Vincenzo Costanzo
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15180-5
Description
Summary:During embryonic development, it is vital to maintain rapid genome duplication. Here, the authors shed light on the mechanism by revealing that SSRP1 stimulates replication origin assembly on somatic nuclei in Xenopus laevis egg extract by promoting histone H1 eviction from somatic chromatin.
ISSN:2041-1723

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