Comparative genomic analysis of eutherian kallikrein genes

• Main Author: Marko Premzl
• Format: Article
• Language: English
• Published: Elsevier 2017-03-01
• Series: Molecular Genetics and Metabolism Reports
• Subjects: Comparative genomic analysis; Gene annotations; Molecular evolution; Phylogenetic analysis; RRID:SCR_014401
• Online Access: http://www.sciencedirect.com/science/article/pii/S2214426916301392

The present study made attempts to update and revise eutherian kallikrein genes implicated in major physiological and pathological processes and in medical molecular diagnostics. Using eutherian comparative genomic analysis protocol and free available genomic sequence assemblies, the tests of reliability of eutherian public genomic sequences annotated most comprehensive curated third party data gene data set of eutherian kallikrein genes including 121 complete coding sequences among 335 potential coding sequences. The present analysis first described 13 major gene clusters of eutherian kallikrein genes, and explained their differential gene expansion patterns. One updated classification and nomenclature of eutherian kallikrein genes was proposed, as new framework of future experiments.