Activation of Dormant Secondary Metabolite Production by Introducing Neomycin Resistance into the Deep-Sea Fungus, Aspergillus versicolor ZBY-3

Activation of Dormant Secondary Metabolite Production by Introducing Neomycin Resistance into the Deep-Sea Fungus, Aspergillus versicolor ZBY-3

A new ultrasound-mediated approach has been developed to introduce neomycin-resistance to activate silent pathways for secondary metabolite production in a bio-inactive, deep-sea fungus, Aspergillus versicolor ZBY-3. Upon treatment of the ZBY-3 spores with a high concentration of neomycin by proper...

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Bibliographic Details
Main Authors: Yuan Dong, Cheng-Bin Cui, Chang-Wei Li, Wei Hua, Chang-Jing Wu, Tian-Jiao Zhu, Qian-Qun Gu
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Marine Drugs
Subjects:
Aspergillus versicolor ZBY-3
deep-sea fungus
neomycin resistance
ultrasound
antitumor activity
secondary metabolite production
Online Access:http://www.mdpi.com/1660-3397/12/8/4326

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