Reverse translation of phase I biomarker findings links the activity of angiotensin-(1–7) to repression of hypoxia inducible factor-1α in vascular sarcomas

Reverse translation of phase I biomarker findings links the activity of angiotensin-(1–7) to repression of hypoxia inducible factor-1α in vascular sarcomas

<p>Abstract</p> <p>Background</p> <p>In a phase I study of angiotensin-(1–7) [Ang-(1–7)], clinical benefit was associated with reduction in plasma placental growth factor (PlGF) concentrations. The current study examines Ang-(1–7) induced changes in biomarkers according...

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Bibliographic Details
Main Authors: Petty W, Aklilu Mebea, Varela Victor A, Lovato James, Savage Paul D, Miller Antonius A
Format: Article
Language:English
Published: BMC 2012-09-01
Series:BMC Cancer
Subjects:
Angiotensin-(1–7)
Sarcoma
Placental growth factor
Online Access:http://www.biomedcentral.com/1471-2407/12/404

Internet

http://www.biomedcentral.com/1471-2407/12/404

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