Bioreactor-Controlled Physoxia Regulates TGF-β Signaling to Alter Extracellular Matrix Synthesis by Human Chondrocytes

Bioreactor-Controlled Physoxia Regulates TGF-β Signaling to Alter Extracellular Matrix Synthesis by Human Chondrocytes

Culturing articular chondrocytes under physiological oxygen tension exerts positive effects on their extracellular matrix synthesis. The underlying molecular mechanisms which enhance the chondrocytic phenotype are, however, still insufficiently elucidated. The TGF-β superfamily of growth fa...

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Bibliographic Details
Main Authors: Holger Jahr, Seval Gunes, Annika-Ricarda Kuhn, Sven Nebelung, Thomas Pufe
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
TGF-β superfamily
physiological oxygen
physoxia
chondrocytic marker expression
TGF-β receptors, type I, type II, type III
Sp1/3
<i>ALK1</i>, <i>ALK5</i>
betaglycan
endoglin
Online Access:https://www.mdpi.com/1422-0067/20/7/1715

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