Loss of Wwox Causes Defective Development of Cerebral Cortex with Hypomyelination in a Rat Model of Lethal Dwarfism with Epilepsy

Loss of Wwox Causes Defective Development of Cerebral Cortex with Hypomyelination in a Rat Model of Lethal Dwarfism with Epilepsy

WW domain-containing oxidoreductase (Wwox) is a putative tumor suppressor. Several germline mutations of Wwox have been associated with infant neurological disorders characterized by epilepsy, growth retardation, and early death. Less is known, however, about the pathological link between Wwox mutat...

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Bibliographic Details
Main Authors: Yuki Tochigi, Yutaka Takamatsu, Jun Nakane, Rika Nakai, Kentaro Katayama, Hiroetsu Suzuki
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
Wwox
cerebral cortex
neuron
oligodendrocyte
Online Access:https://www.mdpi.com/1422-0067/20/14/3596

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