Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia

The characteristics of immune cells in the peripheral nervous system (PNS) are not fully understood. Here the authors examine the transcriptomic profile and ontogeny of macrophages from the PNS, show they are derived from both embryonic and hematopoietic precursors, and that they have some shared fe...

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Main Authors:	Peter L. Wang, Aldrin K. Y. Yim, Ki-Wook Kim, Denis Avey, Rafael S. Czepielewski, Marco Colonna, Jeffrey Milbrandt, Gwendalyn J. Randolph
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16355-w

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spelling	doaj-0d62a1bd7b684c1da747077dfbc3f1392021-05-23T11:15:28ZengNature Publishing GroupNature Communications2041-17232020-05-0111111310.1038/s41467-020-16355-wPeripheral nerve resident macrophages share tissue-specific programming and features of activated microgliaPeter L. Wang0Aldrin K. Y. Yim1Ki-Wook Kim2Denis Avey3Rafael S. Czepielewski4Marco Colonna5Jeffrey Milbrandt6Gwendalyn J. Randolph7Division of Immunobiology, Department of Pathology and Immunology, Washington University School of MedicineDepartment of Genetics, Washington University School of MedicineDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of MedicineDepartment of Genetics, Washington University School of MedicineDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of MedicineDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of MedicineDepartment of Genetics, Washington University School of MedicineDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of MedicineThe characteristics of immune cells in the peripheral nervous system (PNS) are not fully understood. Here the authors examine the transcriptomic profile and ontogeny of macrophages from the PNS, show they are derived from both embryonic and hematopoietic precursors, and that they have some shared features with microglia.https://doi.org/10.1038/s41467-020-16355-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Peter L. Wang Aldrin K. Y. Yim Ki-Wook Kim Denis Avey Rafael S. Czepielewski Marco Colonna Jeffrey Milbrandt Gwendalyn J. Randolph
spellingShingle	Peter L. Wang Aldrin K. Y. Yim Ki-Wook Kim Denis Avey Rafael S. Czepielewski Marco Colonna Jeffrey Milbrandt Gwendalyn J. Randolph Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia Nature Communications
author_facet	Peter L. Wang Aldrin K. Y. Yim Ki-Wook Kim Denis Avey Rafael S. Czepielewski Marco Colonna Jeffrey Milbrandt Gwendalyn J. Randolph
author_sort	Peter L. Wang
title	Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
title_short	Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
title_full	Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
title_fullStr	Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
title_full_unstemmed	Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
title_sort	peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-05-01
description	The characteristics of immune cells in the peripheral nervous system (PNS) are not fully understood. Here the authors examine the transcriptomic profile and ontogeny of macrophages from the PNS, show they are derived from both embryonic and hematopoietic precursors, and that they have some shared features with microglia.
url	https://doi.org/10.1038/s41467-020-16355-w
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Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia

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