Electrophilic oligodeoxynucleotide synthesis using dM-Dmoc for amino protection

Electrophilic oligodeoxynucleotide synthesis using dM-Dmoc for amino protection

Solid-phase synthesis of electrophilic oligodeoxynucleotides (ODNs) was achieved using dimethyl-Dmoc (dM-Dmoc) as amino protecting group. Due to the high steric hindrance of the 2-(propan-2-ylidene)-1,3-dithiane side product from deprotection, the use of excess nucleophilic scavengers such as anilin...

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Bibliographic Details
Main Authors: Shahien Shahsavari, Dhananjani N. A. M. Eriyagama, Bhaskar Halami, Vagarshak Begoyan, Marina Tanasova, Jinsen Chen, Shiyue Fang
Format: Article
Language:English
Published: Beilstein-Institut 2019-05-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Dmoc
electrophilic
oligonucleotides
protecting group
solid-phase synthesis
Online Access:https://doi.org/10.3762/bjoc.15.108

Internet

https://doi.org/10.3762/bjoc.15.108

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