Influence of lactide vs glycolide composition of poly (lactic-co-glycolic acid) polymers on encapsulation of hydrophobic molecules: molecular dynamics and formulation studies
Highlights Microreactor-based continuous process for the synthesis of PLGA nanoparticles. Miscibility of different PLGA polymers and coumarin-6 was evaluated computationally. Flory–Huggins interaction parameter (χ) was superior for shorter PLGA chains, irrespective of their lactide to glycolide rati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2021-09-01
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| Series: | Journal of Materials Science: Materials in Medicine |
| Online Access: | https://doi.org/10.1007/s10856-021-06580-0 |
| Summary: | Highlights Microreactor-based continuous process for the synthesis of PLGA nanoparticles. Miscibility of different PLGA polymers and coumarin-6 was evaluated computationally. Flory–Huggins interaction parameter (χ) was superior for shorter PLGA chains, irrespective of their lactide to glycolide ratio. Polymer chains containing lactide to glycolide ratio of 1:1 resulted in strongest interaction with coumarin-6 due to homogeneous spatial arrangements and superior binding energy. Intra-chain interactions, spatial arrangement, inter-chain binding energies, and polymer–coumarin-6 miscibility influence coiling and flexibility of polymer chains. |
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| ISSN: | 0957-4530 1573-4838 |