Changes of the rats’ heart rate variability caused by chlorpromazine modulation of central noradrenergic neurotransmission during prolonged stress

• Main Author: O. Z. Мelnikova
• Format: Article
• Language: English
• Published: Oles Honchar Dnipropetrovsk National University 2012-03-01
• Series: Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Medicina
• Online Access: http://medicine.dp.ua/index.php/med/article/view/21

It’s established that under the prolonged stress there were changes of geometric and spectral indices of the rats’ heart rate variability (HRV), manifestations of which depended on duration of stressful factors acting and represented the stress reaction development from the stage of anxiety to the exhaustion phase. Application of chlorpromazine at the beginning and against the background of stress blocked the central alpha adrenoceptors and contributed to renewal of the most HRV indices into the limits of control values at the end of experiment. The results of research show that the modulation of functional state of central noradrenergic system plays a great role in the changes of HRV during prolonged stress.