Role of endothelial dysfunction in the pathogenesis of diabetic retinopathy in patients with type 2 diabetes

• Main Authors: I. V. Vorobyeva, D. N. Gigineishvili
• Format: Article
• Language: Russian
• Published: Ophthalmology Publishing Group 2014-07-01
• Series: Oftalʹmologiâ
• Online Access: http://www.ophthalmojournal.com/index.php/opht/article/view/146

The reason for the progressive vision reduction at diabetes mellitus (DM) is diabetic retinopathy (DR). When type 2 diabetes combined with hypertension (Ht), it increases the risk of vision loss by 25 times. In the pathogenesis of DR is important to endothelial dysfunction and a variety of biochemical processes (an excess of intracellular sorbitol, non-enzymatic glycation of proteins, oxidative stress). there is a decrease in generation vasodilating factors, nitric oxide, with a simultaneous increase of endothelin, which causes vasoconstriction. Key processes underlying the development of DR, such as increased vascular permeability, edema, neovasculariza- tion, inflammation and associated with the effects of kallikrein-kinin system. In the pathogenesis of DR can be involved independent intraocular renin-angiotensin system, which is an important mediator of angiogenesis and increased vascular permeability. Damage to the endothelium of retinal vessels leads to ischemia of the retina. there is growth and development of newly formed blood vessels, which may provoke recurrent bleeding.