SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases

Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They play a prominent role in many aspects of physiology and regulate crucial proteins. Modulation of sirtuins can thus be utiliz...

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Bibliographic Details
Main Authors: Ramu Manjula, Kumari Anuja, Francisco J. Alcain
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
neurodegenerative diseases
SIRT1
SIRT2
modulators
neuroprotective mechanism
resveratrol
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.585821/full

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