Calcium antagonism and the vasorelaxation of the rat aorta induced by rotundifolone

Calcium antagonism and the vasorelaxation of the rat aorta induced by rotundifolone

The vasorelaxing activity of rotundifolone (ROT), a major constituent (63.5%) of the essential oil of Mentha x villosa, was tested in male Wistar rats (300-350 g). In isolated rat aortic rings, increasing ROT concentrations (0.3, 1, 10, 100, 300, and 500 µg/ml) inhibited the contractile effects of 1...

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Bibliographic Details
Main Authors:	Guedes D.N., Silva D.F., Barbosa-Filho J.M., Medeiros I.A.
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2004-01-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	Ca2+ mobilization Rat aortic rings Rotundifolone Vasorelaxation Mentha x villosa
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001200014

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