Gallic Acid Inhibits Bladder Cancer T24 Cell Progression Through Mitochondrial Dysfunction and PI3K/Akt/NF-κB Signaling Suppression

Gallic Acid Inhibits Bladder Cancer T24 Cell Progression Through Mitochondrial Dysfunction and PI3K/Akt/NF-κB Signaling Suppression

Gallic acid (GA), a hydrolyzable tannin, has a wide range of pharmacological activities. This study revealed that, GA significantly inhibited T24 cells viability in a concentration- and time- dependent manner. The IC50 of GA stimulating T24 cells for 24, 48, and 72 h were 21.73, 18.62, and 11.59 µg/...

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Bibliographic Details
Main Authors: Maolin Zeng, Yang Su, Kuangyu Li, Dan Jin, Qiaoling Li, Yan Li, Benhong Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
gallic acid
bladder cancer
proliferation
metastasis
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01222/full

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