Stimulus-Specific Expression, Selective Generation and Novel Function of Grass Carp (Ctenopharyngodon idella) IL-12 Isoforms: New Insights Into the Heterodimeric Cytokines in Teleosts

Stimulus-Specific Expression, Selective Generation and Novel Function of Grass Carp (Ctenopharyngodon idella) IL-12 Isoforms: New Insights Into the Heterodimeric Cytokines in Teleosts

Interleukin-12 (IL-12) is a heterodimeric cytokine composed of a p35 subunit specific to IL-12 and a p40 subunit shared with IL-23. In this study, we unveiled the existence of two p35 paralogues in grass carp (named gcp35a and gcp35b). Notably, gcp35a and gcp35b displayed distinct inducible expressi...

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Bibliographic Details
Main Authors: Xingyang Qiu, Hao Sun, Dan Wang, Jingqi Ren, Xinyan Wang, Anying Zhang, Kun Yang, Hong Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
grass carp
Il-12
p35 paralogues
heterodimeric form
Th17-like response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.734535/full

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