Amiloride Improves Endothelial Function and Reduces Vascular Stiffness in Female Mice Fed a Western Diet

Amiloride Improves Endothelial Function and Reduces Vascular Stiffness in Female Mice Fed a Western Diet

Obese premenopausal women lose their sex related cardiovascular disease protection and develop greater arterial stiffening than age matched men. In female mice, we have shown that consumption of a Western diet (WD), high in fat and refined sugars, is associated with endothelial dysfunction and vascu...

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Bibliographic Details
Main Authors: Luis A. Martinez-Lemus, Annayya R. Aroor, Francisco I. Ramirez-Perez, Guanghong Jia, Javad Habibi, Vincent G. DeMarco, Brady Barron, Adam Whaley-Connell, Ravi Nistala, James R. Sowers
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Physiology
Subjects:
EnNaC inhibition
endothelial dysfunction
vascular remodeling
obesity
pulse wave velocity
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00456/full

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