AAV8 transduction capacity is reduced by prior exposure to endosome-like pH conditions

AAV8 transduction capacity is reduced by prior exposure to endosome-like pH conditions

Adeno-associated virus (AAV) is an essential instrument in the neuroscientist’s toolkit, which allows delivery of DNA to provide labeling with fluorescent proteins or genetic instructions to regulate gene expression. In the field of neural regeneration, the transduction of neurons enables the observ...

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Bibliographic Details
Main Authors: Jeffrey A Lowell, Kar Men Mah, John L Bixby, Vance P Lemmon
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Neural Regeneration Research
Subjects:
adeno-associated virus; autolytic; capsid; low ph; protease; proteolytic; temperature; trafficking; transduction; viral inactivation
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=5;spage=851;epage=855;aulast=Lowell

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