Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice

Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice

Alzheimer disease (AD) is the most common form of dementia. Amyloid β-peptide (Aβ) deposition is a major neuropathologic feature of AD. When unfolded or misfolded proteins accumulate in mitochondria, the unfolded protein responses (UPRmt) is initiated. Numerous lines of evidence show that AD pathoge...

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Bibliographic Details
Main Authors: Yang Shen, Mao Ding, Zhaohong Xie, Xiangtian Liu, Hui Yang, Suqin Jin, Shunliang Xu, Zhengyu Zhu, Yun Wang, Dewei Wang, Linlin Xu, Xiaoyan Zhou, Ping Wang, Jianzhong Bi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer disease
UPRmt
mevalonate pathway
sphingolipid biosynthesis pathway
simvastatin
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00568/full

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