FFAR1 activation attenuates histamine-induced myosin light chain phosphorylation and cortical tension development in human airway smooth muscle cells

FFAR1 activation attenuates histamine-induced myosin light chain phosphorylation and cortical tension development in human airway smooth muscle cells

Abstract Background Activation of free fatty acid receptors (FFAR1 and FFAR4) which are G protein-coupled receptors (GPCRs) with established (patho)physiological roles in a variety of obesity-related disorders, induce human airway smooth muscle (HASM) cell proliferation and shortening. We reported a...

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Bibliographic Details
Main Authors: Shengjie Xu, Anthony Schwab, Nikhil Karmacharya, Gaoyuan Cao, Joanna Woo, Nicholas Kim, Steven S. An, Reynold A. Panettieri Jr, Joseph A. Jude
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Respiratory Research
Subjects:
Airway smooth muscle
Free fatty acid receptor 1
Airway hyperresponsiveness
Online Access:https://doi.org/10.1186/s12931-020-01584-w

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