Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses

Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses

Despite extensive research, the development of an effective malaria vaccine remains elusive. The induction of robust and sustained T cell and antibody response by vaccination is an urgent unmet need. Chimeric virus-like particles (VLPs) are a promising vaccine platform. VLPs are composed of multiple...

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Bibliographic Details
Main Authors: David J. Pattinson, Simon H. Apte, Nani Wibowo, Tania Rivera-Hernandez, Penny L. Groves, Anton P. J. Middelberg, Denise L. Doolan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
malaria
vaccine
T cells
virus-like particle
capsomere
murine polyomavirus
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.564627/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.564627/full

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