Repurposing the Electron Transfer Reactant Phenazine Methosulfate (PMS) for the Apoptotic Elimination of Malignant Melanoma Cells through Induction of Lethal Oxidative and Mitochondriotoxic Stress

Repurposing the Electron Transfer Reactant Phenazine Methosulfate (PMS) for the Apoptotic Elimination of Malignant Melanoma Cells through Induction of Lethal Oxidative and Mitochondriotoxic Stress

Redox-directed pharmacophores have shown potential for the apoptotic elimination of cancer cells through chemotherapeutic induction of oxidative stress. Phenazine methosulfate (PMS), a N-alkylphenazinium cation-based redox cycler, is used widely as an electron transfer reactant coupling NAD(P)H gene...

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Bibliographic Details
Main Authors: Anh B. Hua, Rebecca Justiniano, Jessica Perer, Sophia L. Park, Hui Li, Christopher M. Cabello, Georg T. Wondrak
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
reactive oxygen species
cancer
redox cycler
melanoma
oxidative stress
experimental therapeutic
phenazine methosulfate
Online Access:https://www.mdpi.com/2072-6694/11/5/590

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