Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explants

Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explants

<p>Abstract</p> <p>Background</p> <p>Heat shock protein 70 (HSP70) protects inner ear cells from damage and death induced by e.g. heat or toxins. Benzoquinone ansamycin antibiotic geldanamycin (GA) was demonstrated to induce the expression of HSP70 in various animal cel...

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Bibliographic Details
Main Authors: Haupt Heidemarie, Szczepek Agnieszka J, Yu Yang, Mazurek Birgit
Format: Article
Language:English
Published: BMC 2009-09-01
Series:Journal of Biomedical Science
Online Access:http://www.jbiomedsci.com/content/16/1/79

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