Automated cleaning and pre-processing of immunoglobulin gene sequences from high-throughput sequencing

Automated cleaning and pre-processing of immunoglobulin gene sequences from high-throughput sequencing

High throughput sequencing (HTS) yields tens of thousands to millions of sequences that require a large amount of pre-processing work to clean various artifacts. Such cleaning cannot be performed manually. Existing programs are not suitable for immunoglobulin (Ig) genes, which are variable and often...

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Bibliographic Details
Main Authors: Miri eMichaeli, Hila eNoga, Hilla eTabibian-Keissar, Iris eBarshack, Ramit eMehr
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Immunology
Subjects:
high-throughput sequencing
B cell receptor
Computer programs
Immunoglobulin (Ig) genes
insertions and deletions (indels).
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00386/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00386/full

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