Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver

Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver

Squalene synthase (SS) is the first committed enzyme for cholesterol biosynthesis, located at a branch point in the mevalonate pathway. To examine the role of SS in the overall cholesterol metabolism, we transiently overexpressed mouse SS in the livers of mice using adenovirus-mediated gene transfer...

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Bibliographic Details
Main Authors: Hiroaki Okazaki, Fumiko Tazoe, Sachiko Okazaki, Naoyuki Isoo, Kazuhisa Tsukamoto, Motohiro Sekiya, Naoya Yahagi, Yoko Iizuka, Ken Ohashi, Tetsuya Kitamine, Ryu-ichi Tozawa, Toshihiro Inaba, Hiroaki Yagyu, Mitsuyo Okazaki, Hitoshi Shimano, Norihito Shibata, Hiroyuki Arai, Ryo-zo Nagai, Takashi Kadowaki, Jun-ichi Osuga, Shun Ishibashi
Format: Article
Language:English
Published: Elsevier 2006-09-01
Series:Journal of Lipid Research
Subjects:
lipoprotein
adenovirus
hyperlipoproteinemia
3-hydroxy-3-methyglutaryl-CoA reductase
farnesyl diphosphate
mevalonate
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520434613

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