oxLDL inhibits differentiation and functional activity of osteoclasts via scavenger receptor-A mediated autophagy and cathepsin K secretion

Abstract Resorptive activity of osteoclasts is important for maintaining bone homeostasis. Endogenous compounds such as oxidized low density lipoprotein (oxLDL) have been shown to disturb this activity. While some studies have investigated the effects of oxLDL on the process of osteoclastogenesis, t...

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Bibliographic Details
Main Authors: Damilola Dawodu, Margret Patecki, Jan Hegermann, Inna Dumler, Hermann Haller, Yulia Kiyan
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-29963-w

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