Transcriptional and Proteomic Characterization of Telomere-Induced Senescence in a Human Alveolar Epithelial Cell Line

Transcriptional and Proteomic Characterization of Telomere-Induced Senescence in a Human Alveolar Epithelial Cell Line

Cellular senescence due to telomere dysfunction has been hypothesized to play a role in age-associated diseases including idiopathic pulmonary fibrosis (IPF). It has been postulated that paracrine mediators originating from senescent alveolar epithelia signal to surrounding mesenchymal cells and con...

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Bibliographic Details
Main Authors: Daniel I. Sullivan, Mao Jiang, Angela M. Hinchie, Mark G. Roth, Harinath Bahudhanapati, Mehdi Nouraie, Jie Liu, John F. McDyer, Rama K. Mallampalli, Yingze Zhang, Daniel J. Kass, Toren Finkel, Jonathan K. Alder
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Medicine
Subjects:
telomerase
SASP
secretome
IPF
mass spectrometry
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.600626/full

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