Analysis of TSLC1 Expression in Colorectal Cancer Specimens by Immunohistochemistry
Background: The tumor suppressor in lung cancer-1 (TSLC1) is a tumor-suppressor gene. We evaluated the correlation between TSLC1 expression and clinicopathological characteristics of colorectal cancer patients by comparing primary colorectal cancer and adjacent normal colorectal tissues. Methods:...
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| Format: | Article |
| Language: | fas |
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Vesnu Publications
2012-05-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/1519 |
| Summary: | Background: The tumor suppressor in lung cancer-1 (TSLC1) is a tumor-suppressor gene. We evaluated the correlation between TSLC1 expression and clinicopathological characteristics of colorectal cancer patients by comparing primary colorectal cancer and adjacent normal colorectal tissues.
Methods: TSLC1 expression was evaluated in 100 pairs of primary colorectal cancerous and corresponding normal colorectal tissues using immunohistochemical staining on paraffin-embedded sections. The correlation between immunohistochemical findings and clinicopathological factors was then investigated. Age, gender, and clinicopathological presentation of patients were also noted.
Results: TSLC1 was expressed in all tissues. A 71%- down regulation of TSLC1 was colorectal cancer specimens compared to the matched normal tissues. There were statistically significant correlations between TSLC1 expression and stage, location, and lymph node metastasis.
Conclusion: TSLC1 expression may be a favorable biologic marker and a useful prognostic indicator in patients with colorectal cancer.
Keywords: TSLC1, Colorectal cancer, Tumor suppressor gene, Immunohistochemistry |
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| ISSN: | 1027-7595 1735-854X |