Peptide Deformylase (def) is essential in Mycobacterium smegmatis, but the essentiality is compensated by inactivation of methionine formylation

Peptide Deformylase (def) is essential in Mycobacterium smegmatis, but the essentiality is compensated by inactivation of methionine formylation

Abstract Background Co-translational processes in bacteria are attractive drug targets, but while some processes are essential, others are not. The essentiality of Peptide Deformylase (PDF, def) for vitality of mycobacteria was speculated, but never unequivocally proven. Results Here we show by targ...

Full description

Bibliographic Details
Main Authors: Noga Naor, Omer Gadot, Michal Meir, Daniel Barkan
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Microbiology
Subjects:
Mycobacteria
Protein synthesis
Co-translation
Peptide Deformylase
Formyl Transferase
Online Access:http://link.springer.com/article/10.1186/s12866-019-1611-7

Internet

http://link.springer.com/article/10.1186/s12866-019-1611-7

Similar Items