HOXB4 Promotes Hemogenic Endothelium Formation without Perturbing Endothelial Cell Development

HOXB4 Promotes Hemogenic Endothelium Formation without Perturbing Endothelial Cell Development

Summary: Generation of hematopoietic stem cells (HSCs) from pluripotent stem cells, in vitro, holds great promise for regenerative therapies. Primarily, this has been achieved in mouse cells by overexpression of the homeotic selector protein HOXB4. The exact cellular stage at which HOXB4 promotes he...

Full description

Bibliographic Details
Main Authors:	Nadine Teichweyde, Lara Kasperidus, Sebastian Carotta, Valerie Kouskoff, Georges Lacaud, Peter A. Horn, Stefan Heinrichs, Hannes Klump
Format:	Article
Language:	English
Published:	Elsevier 2018-03-01
Series:	Stem Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671118300353

Similar Items

Smooth muscle cells largely develop independently of functional hemogenic endothelium
by: Monika Stefanska, et al.
Published: (2014-01-01)

Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro
by: Eva Garcia-Alegria, et al.
Published: (2018-11-01)

Primitive erythrocytes are generated from hemogenic endothelial cells
by: Monika Stefanska, et al.
Published: (2017-07-01)

The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development
by: Alexia Eliades, et al.
Published: (2016-06-01)

In vitro differentiation of human embryonic stem cells to hemogenic endothelium and blood progenitors via embryoid body formation
by: Eva Garcia-Alegria, et al.
Published: (2021-03-01)

GATA2 Is Dispensable for Specification of Hemogenic Endothelium but Promotes Endothelial-to-Hematopoietic Transition
by: HyunJun Kang, et al.
Published: (2018-07-01)

Sensitive profiling of noncoding transcriptome from pluripotency to hemogenic endothelium
by: Yu-TungChiu, et al.
Published: (2017)

Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential
by: Mi Ae Park, et al.
Published: (2018-05-01)

Blood Generation from Hemogenic Endothelium Proven by Continuous Single Cell Imaging
by: Eilken, Hanna
Published: (2009)

Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta
by: Lyad Zamir, et al.
Published: (2017-03-01)

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels
by: Lukas Stanczuk, et al.
Published: (2015-03-01)

A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17
by: Raedun L. Clarke, et al.
Published: (2015-08-01)

Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation
by: Mauricio Cortes, et al.
Published: (2015-10-01)

Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo
by: Tessa Dignum, et al.
Published: (2021-09-01)

Cell type-specific Runx1 enhancer-reporter mouse lines to study hemogenic endothelium
by: Rode, Christina
Published: (2016)

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells
by: Gene I. Uenishi, et al.
Published: (2018-05-01)

Distinct Waves from the Hemogenic Endothelium Give Rise to Layered Lymphoid Tissue Inducer Cell Ontogeny
by: Milesa Simic, et al.
Published: (2020-08-01)

SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development
by: Sara Cuvertino, et al.
Published: (2016-01-01)

A Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cells
by: Pedro Seco, et al.
Published: (2020-11-01)

Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation
by: Shobhit Saxena, et al.
Published: (2016-05-01)

Proteomic Characterization of Hemogen in Erythropoiesis
by: Somasundaram, Brinda
Published: (2012)

Proteomic Characterization of Hemogen in Erythropoiesis
by: Somasundaram, Brinda
Published: (2012)

Over-expression of c-Myb increases the frequency of hemogenic precursors in the endothelial cell population
by: Dai, Guoyou
Published: (2011)

Direct Reprogramming of Murine Fibroblasts to Hematopoietic Progenitor Cells
by: Kiran Batta, et al.
Published: (2014-12-01)

Spatiotemporal and Functional Heterogeneity of Hematopoietic Stem Cell-Competent Hemogenic Endothelial Cells in Mouse Embryos
by: Yun-Qiao Li, et al.
Published: (2021-08-01)

Identification of the Hemogenic Endothelial Progenitor and Its Direct Precursor in Human Pluripotent Stem Cell Differentiation Cultures
by: Kyung-Dal Choi, et al.
Published: (2012-09-01)

Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification
by: Jingyao Qiu, et al.
Published: (2020-12-01)

Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming
by: Andreia M. Gomes, et al.
Published: (2018-12-01)

HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition
by: Roshana Thambyrajah, et al.
Published: (2018-04-01)

In Vivo Repopulating Activity Emerges at the Onset of Hematopoietic Specification during Embryonic Stem Cell Differentiation
by: Stella Pearson, et al.
Published: (2015-03-01)

Expression of HOXB4 in endometrial tissues from women with or without endometriosis
by: AlKusayer, Ghadeer M.
Published: (2015)

Characterization of HOXB7 and HOXB9 expression in breast cancer patients
by: João Andrade Mouta
Published: (2019)

HOXB1 Founder Mutation in Humans Recapitulates the Phenotype of Hoxb1[superscript −/−] Mice
by: Webb, Bryn D, et al.
Published: (2014)

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1
by: Hongtao Wang, et al.
Published: (2018-02-01)

Relaxed selection in erythropoietic gene hemogen among high-latitude Antarctic notothenioids
Published: ()

MiR-10 represses HoxB1a and HoxB3a in zebrafish.
by: Joost M Woltering, et al.
Published: (2008-01-01)

Hemogenic Endothelial Cells Can Transition to Hematopoietic Stem Cells through a B-1 Lymphocyte-Biased State during Maturation in the Mouse Embryo
by: Michihiro Kobayashi, et al.
Published: (2019-07-01)

HOXB genes function in Breast Cancer
by: Mafalda Araújo Pereira
Published: (2019)

The Role of HOXB13 in Prostate Cancer
by: Marta Ribeiro José Cardoso
Published: (2019)

Long noncoding RNA HOXB13‐AS1 regulates HOXB13 gene methylation by interacting with EZH2 in glioma
by: Yu Xiong, et al.
Published: (2018-09-01)

Cannot write session to /tmp/vufind_sessions/sess_6bi4p13vn1dbia220loht84c7n