A Novel Dual-Targeted α-Helical Peptide With Potent Antifungal Activity Against Fluconazole-Resistant Candida albicans Clinical Isolates

A Novel Dual-Targeted α-Helical Peptide With Potent Antifungal Activity Against Fluconazole-Resistant Candida albicans Clinical Isolates

Due to compromised immune system, fungal infection incidences have markedly increased in the last few decades. Pathogenic fungi have developed resistance to the clinically available antifungal agents. Antifungal resistance poses a great challenge to clinical treatment and has stimulated the demand f...

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Bibliographic Details
Main Authors: Yang Yang, Chenxi Wang, Nan Gao, Yinfeng Lyu, Licong Zhang, Sujiang Zhang, Jiajun Wang, Anshan Shan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Microbiology
Subjects:
antimicrobial peptides
antifungal activity
fluconazole resistance
Candida albicans
membrane disruption
ROS production
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.548620/full

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