Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease

Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease

Niemann-Pick type C1 (NPC1) disease is caused by a deleterious mutation in the Npc1 gene, causing lysosomal accumulation of unesterified cholesterol and sphingolipids. Consequently, NPC1 disease patients suffer from severe neurovisceral symptoms which, in the absence of effective treatments, result...

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Bibliographic Details
Main Authors: Tom Houben, Inês Magro dos Reis, Yvonne Oligschlaeger, Hellen Steinbusch, Marion J. J. Gijbels, Tim Hendrikx, Christoph J. Binder, David Cassiman, Marit Westerterp, Jos Prickaerts, Ronit Shiri-Sverdlov
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
Niemann-Pick type C1
oxidized low-density lipoprotein
pneumococcal immunization
inflammation
lipid metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03089/full

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