Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer

Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer

The total synthesis of (3R,5R)-harzialactone A (1) and its (3R,5S)-isomer (2) is described. Epoxide opening with thioacetal and diastereoselective reductions are used as key reactions.

Bibliographic Details
Main Authors: Gowravaram Sabitha, Rangavajjula Srinivas, Sukant K. Das, Jhillu S. Yadav
Format: Article
Language:English
Published: Beilstein-Institut 2010-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
dithiane
harzialactone A
hydroxyl directed reduction
stereoisomer
Online Access:https://doi.org/10.3762/bjoc.6.8
Description
Summary:The total synthesis of (3R,5R)-harzialactone A (1) and its (3R,5S)-isomer (2) is described. Epoxide opening with thioacetal and diastereoselective reductions are used as key reactions.
ISSN:1860-5397

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