Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1

Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1

Six mutations in the salt-inducible kinase 1 (SIK1)-coding gene have been identified in patients with early infantile epileptic encephalopathy (EIEE-30) accompanied by autistic symptoms. Two of the mutations are non-sense mutations that truncate the C-terminal region of SIK1. It has been shown that...

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Bibliographic Details
Main Authors: Moataz Badawi, Takuma Mori, Taiga Kurihara, Takahiro Yoshizawa, Katsuhiro Nohara, Emi Kouyama-Suzuki, Toru Yanagawa, Yoshinori Shirai, Katsuhiko Tabuchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
SIK1
EIEE-30
ASD
synaptic balance
risperidone
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.706494/full

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