Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy

Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy

Random-pattern skin flap replantation is commonly used to repair skin defects during plastic and reconstructive surgery. However, flap necrosis due to ischemia and ischemia–reperfusion injury limits clinical applications. Betulinic acid, a plant-derived pentacyclic triterpene, may facilitate flap su...

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Bibliographic Details
Main Authors: Jiafeng Li, Guodong Bao, Eman ALyafeai, Jian Ding, Shihen Li, Shimin Sheng, Zitong Shen, Zhenyu Jia, Chen Lin, Chenxi Zhang, Zhiling Lou, Huazi Xu, Weiyang Gao, Kailiang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
betulinic acid
random-pattern skin flaps
autophagy
angiogenesis
apoptosis
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01017/full

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