Pre-exposure to Lower-Level Noise Mitigates Cochlear Synaptic Loss Induced by High-Level Noise
The auditory sensory organs appear to be less damaged by exposure to high-level noise that is presented after exposure to non-traumatizing low-level noise. This phenomenon is known as the toughening or conditioning effect. Functionally, it is manifested by a reduced threshold shift, and morphologica...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnsys.2020.00025/full |
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|---|---|
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Liqiang Fan Liqiang Fan Liqiang Fan Zhen Zhang Zhen Zhang Zhen Zhang Hui Wang Hui Wang Hui Wang Chunyan Li Chunyan Li Chunyan Li Yazhi Xing Yazhi Xing Yazhi Xing Shankai Yin Shankai Yin Shankai Yin Zhengnong Chen Zhengnong Chen Zhengnong Chen Jian Wang Jian Wang Jian Wang Jian Wang |
| spellingShingle |
Liqiang Fan Liqiang Fan Liqiang Fan Zhen Zhang Zhen Zhang Zhen Zhang Hui Wang Hui Wang Hui Wang Chunyan Li Chunyan Li Chunyan Li Yazhi Xing Yazhi Xing Yazhi Xing Shankai Yin Shankai Yin Shankai Yin Zhengnong Chen Zhengnong Chen Zhengnong Chen Jian Wang Jian Wang Jian Wang Jian Wang Pre-exposure to Lower-Level Noise Mitigates Cochlear Synaptic Loss Induced by High-Level Noise Frontiers in Systems Neuroscience noise exposure synaptic loss coding-in-noise deficits Guinea pigs toughening conditioning |
| author_facet |
Liqiang Fan Liqiang Fan Liqiang Fan Zhen Zhang Zhen Zhang Zhen Zhang Hui Wang Hui Wang Hui Wang Chunyan Li Chunyan Li Chunyan Li Yazhi Xing Yazhi Xing Yazhi Xing Shankai Yin Shankai Yin Shankai Yin Zhengnong Chen Zhengnong Chen Zhengnong Chen Jian Wang Jian Wang Jian Wang Jian Wang |
| author_sort |
Liqiang Fan |
| title |
Pre-exposure to Lower-Level Noise Mitigates Cochlear Synaptic Loss Induced by High-Level Noise |
| title_short |
Pre-exposure to Lower-Level Noise Mitigates Cochlear Synaptic Loss Induced by High-Level Noise |
| title_full |
Pre-exposure to Lower-Level Noise Mitigates Cochlear Synaptic Loss Induced by High-Level Noise |
| title_fullStr |
Pre-exposure to Lower-Level Noise Mitigates Cochlear Synaptic Loss Induced by High-Level Noise |
| title_full_unstemmed |
Pre-exposure to Lower-Level Noise Mitigates Cochlear Synaptic Loss Induced by High-Level Noise |
| title_sort |
pre-exposure to lower-level noise mitigates cochlear synaptic loss induced by high-level noise |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Systems Neuroscience |
| issn |
1662-5137 |
| publishDate |
2020-05-01 |
| description |
The auditory sensory organs appear to be less damaged by exposure to high-level noise that is presented after exposure to non-traumatizing low-level noise. This phenomenon is known as the toughening or conditioning effect. Functionally, it is manifested by a reduced threshold shift, and morphologically by a reduced hair cell loss. However, it remains unclear whether prior exposure to toughening noise can mitigate the synaptic loss induced by exposure to damaging noise. Since the cochlear afferent synapse between the inner hair cells and primary auditory neurons has been identified as a novel site involved in noise-induced cochlear damage, we were interested in assessing whether this synapse can be toughened. In the present study, the synaptic loss was induced by a damaging noise exposure (106 dB SPL) and compared across Guinea pigs who had and had not been previously exposed to a toughening noise (85 dB SPL). Results revealed that the toughening noise heavily reduced the synaptic loss observed 1 day after exposure to the damaging noise. Although it was significant, the protective effect of the toughening noise on permanent synaptic loss was much smaller. Compared with cases in the control group without noise exposure, coding deficits were seen in both toughened groups, as reflected in the compound action potential (CAP) by signals with amplitude modulation. In general, the pre-exposure to the toughening noise resulted in a significantly reduced synaptic loss by the high-level noise. However, this morphological protection was not accompanied by a robust functional benefit. |
| topic |
noise exposure synaptic loss coding-in-noise deficits Guinea pigs toughening conditioning |
| url |
https://www.frontiersin.org/article/10.3389/fnsys.2020.00025/full |
| work_keys_str_mv |
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doaj-0cb7af6ca8a1465d8beb9dc45a546e8c2020-11-25T02:59:24ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372020-05-011410.3389/fnsys.2020.00025530196Pre-exposure to Lower-Level Noise Mitigates Cochlear Synaptic Loss Induced by High-Level NoiseLiqiang Fan0Liqiang Fan1Liqiang Fan2Zhen Zhang3Zhen Zhang4Zhen Zhang5Hui Wang6Hui Wang7Hui Wang8Chunyan Li9Chunyan Li10Chunyan Li11Yazhi Xing12Yazhi Xing13Yazhi Xing14Shankai Yin15Shankai Yin16Shankai Yin17Zhengnong Chen18Zhengnong Chen19Zhengnong Chen20Jian Wang21Jian Wang22Jian Wang23Jian Wang24Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaOtolaryngology Institute of Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaOtolaryngology Institute of Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaOtolaryngology Institute of Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaOtolaryngology Institute of Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaOtolaryngology Institute of Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaOtolaryngology Institute of Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaOtolaryngology Institute of Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaOtolaryngology Institute of Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaSchool of Communication Sciences and Disorders, Faculty of Health, Dalhousie University, Halifax, NS, CanadaThe auditory sensory organs appear to be less damaged by exposure to high-level noise that is presented after exposure to non-traumatizing low-level noise. This phenomenon is known as the toughening or conditioning effect. Functionally, it is manifested by a reduced threshold shift, and morphologically by a reduced hair cell loss. However, it remains unclear whether prior exposure to toughening noise can mitigate the synaptic loss induced by exposure to damaging noise. Since the cochlear afferent synapse between the inner hair cells and primary auditory neurons has been identified as a novel site involved in noise-induced cochlear damage, we were interested in assessing whether this synapse can be toughened. In the present study, the synaptic loss was induced by a damaging noise exposure (106 dB SPL) and compared across Guinea pigs who had and had not been previously exposed to a toughening noise (85 dB SPL). Results revealed that the toughening noise heavily reduced the synaptic loss observed 1 day after exposure to the damaging noise. Although it was significant, the protective effect of the toughening noise on permanent synaptic loss was much smaller. Compared with cases in the control group without noise exposure, coding deficits were seen in both toughened groups, as reflected in the compound action potential (CAP) by signals with amplitude modulation. In general, the pre-exposure to the toughening noise resulted in a significantly reduced synaptic loss by the high-level noise. However, this morphological protection was not accompanied by a robust functional benefit.https://www.frontiersin.org/article/10.3389/fnsys.2020.00025/fullnoise exposuresynaptic losscoding-in-noise deficitsGuinea pigstougheningconditioning |