Oridonin Could Inhibit Inflammation and T-cell Immunoglobulin and Mucin-3/Galectin-9 (TIM-3/Gal-9) Autocrine Loop in the Acute Myeloid Leukemia Cell Line (U937) as Compared to Doxorubicin

Oridonin Could Inhibit Inflammation and T-cell Immunoglobulin and Mucin-3/Galectin-9 (TIM-3/Gal-9) Autocrine Loop in the Acute Myeloid Leukemia Cell Line (U937) as Compared to Doxorubicin

The T-cell immunoglobulin and mucin-3 (TIM-3)/galectin-9 (Gal-9) autocrine loop is an indispensable signaling in acute myeloid leukemia (AML) cells, which induces their self-renewal through activation of nuclear factor-kappa b (NF-kB) and β-catenin pathways. In this study, we evaluated the effects...

Full description

Bibliographic Details
Main Authors: Farzad Nasri, Fatemeh Sadeghi, Nafiseh Behranvand, Azam Samei, Mohammad Reza Bolouri, Tahereh Azari, Elaheh Abdollahi, Foad Ghazizadeh, Manijeh Motevalian, Zuhair Mohammad Hassan, Reza Falak
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2020-12-01
Series:Iranian Journal of Allergy, Asthma and Immunology
Subjects:
Acute myeloid leukemia
Doxorubicin
Galectin 9
NF-kappa B
Oridonin
Online Access:https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2952

Similar Items

Similar Items