A DNA Vaccine Protects Human Immune Cells against Zika Virus Infection in Humanized Mice

A DNA Vaccine Protects Human Immune Cells against Zika Virus Infection in Humanized Mice

A DNA vaccine encoding prM and E protein has been shown to induce protection against Zika virus (ZIKV) infection in mice and monkeys. However, its effectiveness in humans remains undefined. Moreover, identification of which immune cell types are specifically infected in humans is unclear. We show th...

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Bibliographic Details
Main Authors: Guohua Yi, Xuequn Xu, Sojan Abraham, Sean Petersen, Hua Guo, Nora Ortega, Premlata Shankar, N. Manjunath
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:EBioMedicine
Subjects:
Zika virus (ZIKV)
DNA vaccine
Humanized DRAG mice
Neutralizing antibody
B cell infection
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417303985

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http://www.sciencedirect.com/science/article/pii/S2352396417303985

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