CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways

CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways

Persistent infection with human papillomavirus (HPV) and immune surveillance failure may be the initiating factors for the carcinogenesis of cervical squamous cell carcinoma (CSCC). HPV infection might affect the innate immune pathway of cervical epithelial cells that constitute the “microenvironmen...

Full description

Bibliographic Details
Main Authors: Xiaona Chen, Hui He, Yue Xiao, Ayshamgul Hasim, Jianlin Yuan, Min Ye, Xin Li, Yi Hao, Xia Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
human papillary virus
CXCL10-CXCR3 axis
innate and adaptive immune responses pathways
TLR signaling pathways
PD-L1
cervical cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.629350/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.629350/full

Similar Items