Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects with Prediabetes and Type 2 Diabetes Mellitus

Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects with Prediabetes and Type 2 Diabetes Mellitus

Background and aimHyperglycemia-mediated oxidative stress impedes cell-reparative process like autophagy, which has been implicated in impairment of β-cell function in type 2 diabetes mellitus (T2DM). However, the role of mitophagy (selective mitochondrial autophagy) in progression of hyperglycemia...

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Bibliographic Details
Main Authors: Shipra Bhansali, Anil Bhansali, Rama Walia, Uma Nahar Saikia, Veena Dhawan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Endocrinology
Subjects:
reactive oxygen species
mitochondrial oxidative stress
mitophagy
prediabetes
type 2 diabetes mellitus
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00347/full

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