HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study
Abstract Background Preeclampsia and gestational hypertensive disorders are thought to occur due to endothelial cell dysfunction and abnormal placentation, triggered by angiogenesis-related factors yet undetermined. The aim of this study was to investigate whether a genetic polymorphism (SNP) of His...
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doaj-0ca65eaaa929428da886be084576e6702021-04-02T15:59:59ZengBMCBMC Medical Genetics1471-23502018-03-011911710.1186/s12881-018-0550-8HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot studyEvangelia Elenis0Alkistis Skalkidou1Agneta Skoog-Svanberg2Gunilla Sydsjö3Anneli Stavreus-Evers4Helena Åkerud5Department of Women’s and Children’s Health, Uppsala UniversityDepartment of Women’s and Children’s Health, Uppsala UniversityDepartment of Women’s and Children’s Health, Uppsala UniversityObstetrics and gynaecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping UniversityDepartment of Women’s and Children’s Health, Uppsala UniversityDepartment of Women’s and Children’s Health, Uppsala UniversityAbstract Background Preeclampsia and gestational hypertensive disorders are thought to occur due to endothelial cell dysfunction and abnormal placentation, triggered by angiogenesis-related factors yet undetermined. The aim of this study was to investigate whether a genetic polymorphism (SNP) of Histidine-rich glycoprotein (HRG), HRG C633T SNP, is associated with gestational hypertensive disorders. Methods It was performed a nested case-control study from the BASIC Cohort of Uppsala University Hospital comprising 92 women diagnosed with gestational hypertensive disorders without other comorbidities and 200 women with full term uncomplicated pregnancies, all genotyped regarding HRG C633T SNP. Results The genetic analysis of the study sample showed that C/C genotype was more prevalent among controls. The presence of the T-allele showed a tendency towards an increased risk of gestational hypertensive disorders. After clustering the study participants based on their genotype, it was observed that the odds for gestational hypertensive disorders among heterozygous C/T or homozygous T/T carriers were higher compared to homozygous C/C carriers [OR 1.72, 95% CI (1.04–2.84)]. The association remained significant even after adjustment for maternal age, BMI and parity. Conclusions The HRG C633T genotype seems to be associated with gestational hypertensive disorders, and as part of a greater algorithm, might contribute in the future to the prediction of the individual susceptibility to the condition.http://link.springer.com/article/10.1186/s12881-018-0550-8AngiogenesisGestational hypertensive disordersHRGHRG C633T SNPPreeclampsia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Evangelia Elenis Alkistis Skalkidou Agneta Skoog-Svanberg Gunilla Sydsjö Anneli Stavreus-Evers Helena Åkerud |
spellingShingle |
Evangelia Elenis Alkistis Skalkidou Agneta Skoog-Svanberg Gunilla Sydsjö Anneli Stavreus-Evers Helena Åkerud HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study BMC Medical Genetics Angiogenesis Gestational hypertensive disorders HRG HRG C633T SNP Preeclampsia |
author_facet |
Evangelia Elenis Alkistis Skalkidou Agneta Skoog-Svanberg Gunilla Sydsjö Anneli Stavreus-Evers Helena Åkerud |
author_sort |
Evangelia Elenis |
title |
HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study |
title_short |
HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study |
title_full |
HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study |
title_fullStr |
HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study |
title_full_unstemmed |
HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study |
title_sort |
hrg c633t polymorphism and risk of gestational hypertensive disorders: a pilot study |
publisher |
BMC |
series |
BMC Medical Genetics |
issn |
1471-2350 |
publishDate |
2018-03-01 |
description |
Abstract Background Preeclampsia and gestational hypertensive disorders are thought to occur due to endothelial cell dysfunction and abnormal placentation, triggered by angiogenesis-related factors yet undetermined. The aim of this study was to investigate whether a genetic polymorphism (SNP) of Histidine-rich glycoprotein (HRG), HRG C633T SNP, is associated with gestational hypertensive disorders. Methods It was performed a nested case-control study from the BASIC Cohort of Uppsala University Hospital comprising 92 women diagnosed with gestational hypertensive disorders without other comorbidities and 200 women with full term uncomplicated pregnancies, all genotyped regarding HRG C633T SNP. Results The genetic analysis of the study sample showed that C/C genotype was more prevalent among controls. The presence of the T-allele showed a tendency towards an increased risk of gestational hypertensive disorders. After clustering the study participants based on their genotype, it was observed that the odds for gestational hypertensive disorders among heterozygous C/T or homozygous T/T carriers were higher compared to homozygous C/C carriers [OR 1.72, 95% CI (1.04–2.84)]. The association remained significant even after adjustment for maternal age, BMI and parity. Conclusions The HRG C633T genotype seems to be associated with gestational hypertensive disorders, and as part of a greater algorithm, might contribute in the future to the prediction of the individual susceptibility to the condition. |
topic |
Angiogenesis Gestational hypertensive disorders HRG HRG C633T SNP Preeclampsia |
url |
http://link.springer.com/article/10.1186/s12881-018-0550-8 |
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