HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study

Abstract Background Preeclampsia and gestational hypertensive disorders are thought to occur due to endothelial cell dysfunction and abnormal placentation, triggered by angiogenesis-related factors yet undetermined. The aim of this study was to investigate whether a genetic polymorphism (SNP) of His...

Full description

Bibliographic Details
Main Authors: Evangelia Elenis, Alkistis Skalkidou, Agneta Skoog-Svanberg, Gunilla Sydsjö, Anneli Stavreus-Evers, Helena Åkerud
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Medical Genetics
Subjects:
HRG
Online Access:http://link.springer.com/article/10.1186/s12881-018-0550-8
id doaj-0ca65eaaa929428da886be084576e670
record_format Article
spelling doaj-0ca65eaaa929428da886be084576e6702021-04-02T15:59:59ZengBMCBMC Medical Genetics1471-23502018-03-011911710.1186/s12881-018-0550-8HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot studyEvangelia Elenis0Alkistis Skalkidou1Agneta Skoog-Svanberg2Gunilla Sydsjö3Anneli Stavreus-Evers4Helena Åkerud5Department of Women’s and Children’s Health, Uppsala UniversityDepartment of Women’s and Children’s Health, Uppsala UniversityDepartment of Women’s and Children’s Health, Uppsala UniversityObstetrics and gynaecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping UniversityDepartment of Women’s and Children’s Health, Uppsala UniversityDepartment of Women’s and Children’s Health, Uppsala UniversityAbstract Background Preeclampsia and gestational hypertensive disorders are thought to occur due to endothelial cell dysfunction and abnormal placentation, triggered by angiogenesis-related factors yet undetermined. The aim of this study was to investigate whether a genetic polymorphism (SNP) of Histidine-rich glycoprotein (HRG), HRG C633T SNP, is associated with gestational hypertensive disorders. Methods It was performed a nested case-control study from the BASIC Cohort of Uppsala University Hospital comprising 92 women diagnosed with gestational hypertensive disorders without other comorbidities and 200 women with full term uncomplicated pregnancies, all genotyped regarding HRG C633T SNP. Results The genetic analysis of the study sample showed that C/C genotype was more prevalent among controls. The presence of the T-allele showed a tendency towards an increased risk of gestational hypertensive disorders. After clustering the study participants based on their genotype, it was observed that the odds for gestational hypertensive disorders among heterozygous C/T or homozygous T/T carriers were higher compared to homozygous C/C carriers [OR 1.72, 95% CI (1.04–2.84)]. The association remained significant even after adjustment for maternal age, BMI and parity. Conclusions The HRG C633T genotype seems to be associated with gestational hypertensive disorders, and as part of a greater algorithm, might contribute in the future to the prediction of the individual susceptibility to the condition.http://link.springer.com/article/10.1186/s12881-018-0550-8AngiogenesisGestational hypertensive disordersHRGHRG C633T SNPPreeclampsia
collection DOAJ
language English
format Article
sources DOAJ
author Evangelia Elenis
Alkistis Skalkidou
Agneta Skoog-Svanberg
Gunilla Sydsjö
Anneli Stavreus-Evers
Helena Åkerud
spellingShingle Evangelia Elenis
Alkistis Skalkidou
Agneta Skoog-Svanberg
Gunilla Sydsjö
Anneli Stavreus-Evers
Helena Åkerud
HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study
BMC Medical Genetics
Angiogenesis
Gestational hypertensive disorders
HRG
HRG C633T SNP
Preeclampsia
author_facet Evangelia Elenis
Alkistis Skalkidou
Agneta Skoog-Svanberg
Gunilla Sydsjö
Anneli Stavreus-Evers
Helena Åkerud
author_sort Evangelia Elenis
title HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study
title_short HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study
title_full HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study
title_fullStr HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study
title_full_unstemmed HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study
title_sort hrg c633t polymorphism and risk of gestational hypertensive disorders: a pilot study
publisher BMC
series BMC Medical Genetics
issn 1471-2350
publishDate 2018-03-01
description Abstract Background Preeclampsia and gestational hypertensive disorders are thought to occur due to endothelial cell dysfunction and abnormal placentation, triggered by angiogenesis-related factors yet undetermined. The aim of this study was to investigate whether a genetic polymorphism (SNP) of Histidine-rich glycoprotein (HRG), HRG C633T SNP, is associated with gestational hypertensive disorders. Methods It was performed a nested case-control study from the BASIC Cohort of Uppsala University Hospital comprising 92 women diagnosed with gestational hypertensive disorders without other comorbidities and 200 women with full term uncomplicated pregnancies, all genotyped regarding HRG C633T SNP. Results The genetic analysis of the study sample showed that C/C genotype was more prevalent among controls. The presence of the T-allele showed a tendency towards an increased risk of gestational hypertensive disorders. After clustering the study participants based on their genotype, it was observed that the odds for gestational hypertensive disorders among heterozygous C/T or homozygous T/T carriers were higher compared to homozygous C/C carriers [OR 1.72, 95% CI (1.04–2.84)]. The association remained significant even after adjustment for maternal age, BMI and parity. Conclusions The HRG C633T genotype seems to be associated with gestational hypertensive disorders, and as part of a greater algorithm, might contribute in the future to the prediction of the individual susceptibility to the condition.
topic Angiogenesis
Gestational hypertensive disorders
HRG
HRG C633T SNP
Preeclampsia
url http://link.springer.com/article/10.1186/s12881-018-0550-8
work_keys_str_mv AT evangeliaelenis hrgc633tpolymorphismandriskofgestationalhypertensivedisordersapilotstudy
AT alkistisskalkidou hrgc633tpolymorphismandriskofgestationalhypertensivedisordersapilotstudy
AT agnetaskoogsvanberg hrgc633tpolymorphismandriskofgestationalhypertensivedisordersapilotstudy
AT gunillasydsjo hrgc633tpolymorphismandriskofgestationalhypertensivedisordersapilotstudy
AT annelistavreusevers hrgc633tpolymorphismandriskofgestationalhypertensivedisordersapilotstudy
AT helenaakerud hrgc633tpolymorphismandriskofgestationalhypertensivedisordersapilotstudy
_version_ 1721558291318833152