mTOR-dependent phosphorylation controls TFEB nuclear export

mTOR-dependent phosphorylation controls TFEB nuclear export

On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that is recognized by the exportin CRM1, and show that dual phosphorylation at S142 and S138 by mTOR accelerates export of TFEB.

Bibliographic Details
Main Authors: Gennaro Napolitano, Alessandra Esposito, Heejun Choi, Maria Matarese, Valerio Benedetti, Chiara Di Malta, Jlenia Monfregola, Diego Luis Medina, Jennifer Lippincott-Schwartz, Andrea Ballabio
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05862-6
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spelling doaj-0ca34c106f93485d8615cf33135d22a22021-05-11T10:20:56ZengNature Publishing GroupNature Communications2041-17232018-08-019111010.1038/s41467-018-05862-6mTOR-dependent phosphorylation controls TFEB nuclear exportGennaro Napolitano0Alessandra Esposito1Heejun Choi2Maria Matarese3Valerio Benedetti4Chiara Di Malta5Jlenia Monfregola6Diego Luis Medina7Jennifer Lippincott-Schwartz8Andrea Ballabio9Telethon Institute of Genetics and Medicine (TIGEM)Telethon Institute of Genetics and Medicine (TIGEM)Howard Hughes Medical InstituteTelethon Institute of Genetics and Medicine (TIGEM)Telethon Institute of Genetics and Medicine (TIGEM)Telethon Institute of Genetics and Medicine (TIGEM)Telethon Institute of Genetics and Medicine (TIGEM)Telethon Institute of Genetics and Medicine (TIGEM)Howard Hughes Medical InstituteTelethon Institute of Genetics and Medicine (TIGEM)On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that is recognized by the exportin CRM1, and show that dual phosphorylation at S142 and S138 by mTOR accelerates export of TFEB.https://doi.org/10.1038/s41467-018-05862-6
collection DOAJ
language English
format Article
sources DOAJ
author Gennaro Napolitano
Alessandra Esposito
Heejun Choi
Maria Matarese
Valerio Benedetti
Chiara Di Malta
Jlenia Monfregola
Diego Luis Medina
Jennifer Lippincott-Schwartz
Andrea Ballabio
spellingShingle Gennaro Napolitano
Alessandra Esposito
Heejun Choi
Maria Matarese
Valerio Benedetti
Chiara Di Malta
Jlenia Monfregola
Diego Luis Medina
Jennifer Lippincott-Schwartz
Andrea Ballabio
mTOR-dependent phosphorylation controls TFEB nuclear export
Nature Communications
author_facet Gennaro Napolitano
Alessandra Esposito
Heejun Choi
Maria Matarese
Valerio Benedetti
Chiara Di Malta
Jlenia Monfregola
Diego Luis Medina
Jennifer Lippincott-Schwartz
Andrea Ballabio
author_sort Gennaro Napolitano
title mTOR-dependent phosphorylation controls TFEB nuclear export
title_short mTOR-dependent phosphorylation controls TFEB nuclear export
title_full mTOR-dependent phosphorylation controls TFEB nuclear export
title_fullStr mTOR-dependent phosphorylation controls TFEB nuclear export
title_full_unstemmed mTOR-dependent phosphorylation controls TFEB nuclear export
title_sort mtor-dependent phosphorylation controls tfeb nuclear export
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that is recognized by the exportin CRM1, and show that dual phosphorylation at S142 and S138 by mTOR accelerates export of TFEB.
url https://doi.org/10.1038/s41467-018-05862-6
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AT alessandraesposito mtordependentphosphorylationcontrolstfebnuclearexport
AT heejunchoi mtordependentphosphorylationcontrolstfebnuclearexport
AT mariamatarese mtordependentphosphorylationcontrolstfebnuclearexport
AT valeriobenedetti mtordependentphosphorylationcontrolstfebnuclearexport
AT chiaradimalta mtordependentphosphorylationcontrolstfebnuclearexport
AT jleniamonfregola mtordependentphosphorylationcontrolstfebnuclearexport
AT diegoluismedina mtordependentphosphorylationcontrolstfebnuclearexport
AT jenniferlippincottschwartz mtordependentphosphorylationcontrolstfebnuclearexport
AT andreaballabio mtordependentphosphorylationcontrolstfebnuclearexport
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