DR2S: an integrated algorithm providing reference-grade haplotype sequences from heterozygous samples

DR2S: an integrated algorithm providing reference-grade haplotype sequences from heterozygous samples

Abstract Background High resolution HLA genotyping of donors and recipients is a crucially important prerequisite for haematopoetic stem-cell transplantation and relies heavily on the quality and completeness of immunogenetic reference sequence databases of allelic variation. Results Here, we report...

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Bibliographic Details
Main Authors: Steffen Klasberg, Alexander H. Schmidt, Vinzenz Lange, Gerhard Schöfl
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Bioinformatics
Subjects:
Sequence analysis
Reference sequencing
Phasing
Third-generation sequencing
HLA
KIR
Online Access:https://doi.org/10.1186/s12859-021-04153-0

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