External Validity of Randomized Controlled Trials on Alzheimer’s Disease: The Biases of Frailty and Biological Aging

External Validity of Randomized Controlled Trials on Alzheimer’s Disease: The Biases of Frailty and Biological Aging

To date, the external validity of randomized controlled trials (RCTs) on Alzheimer’s disease (AD) has been assessed only considering monodimensional variables. Nevertheless, looking at isolated and single characteristics cannot guarantee a sufficient level of appreciation of the AD patients’ complex...

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Bibliographic Details
Main Authors: Marco Canevelli, Alessandro Trebbastoni, Federica Quarata, Fabrizia D’Antonio, Matteo Cesari, Carlo de Lena, Giuseppe Bruno
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Neurology
Subjects:
Alzheimer’s disease
frailty
randomized controlled trial
external validity
aging
holistic approach
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2017.00628/full

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