AUY922 induces retinal toxicity through attenuating TRPM1

AUY922 induces retinal toxicity through attenuating TRPM1

Abstract Background Ocular adverse events are common dose-limiting toxicities in cancer patients treated with HSP90 inhibitors, such as AUY922; however, the pathology and molecular mechanisms that mediate AUY922-induced retinal toxicity remain undescribed. Methods The impact of AUY922 on mouse retin...

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Main Authors: Che-Hung Shen, Chi-Che Hsieh, Kuan-Ying Jiang, Chih-Yu Lin, Nai-Jung Chiang, Ting-Wei Li, Chun-Ting Yen, Wan-Ju Chen, Daw-Yang Hwang, Li-Tzong Chen
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Biomedical Science
Subjects:
Retinal toxicity
Photoreceptor
HSP90
CDC37
AUY922
TRPM1
Online Access:https://doi.org/10.1186/s12929-021-00751-5

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